The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes
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چکیده
منابع مشابه
The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes
The multimeric membrane-tethering complexes TRAPPI and TRAPPII share seven subunits, of which four (Bet3p, Bet5p, Trs23p, and Trs31p) are minimally needed to activate the Rab GTPase Ypt1p in an event preceding membrane fusion. Here, we present the structure of a heteropentameric TRAPPI assembly complexed with Ypt1p. We propose that TRAPPI facilitates nucleotide exchange primarily by stabilizing...
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ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.04.049